Revolutionizing Wellness: Unleashing the Power of CBD, CBG, and Bakuchiol Against Inflammation
“Inflammation should be addressed via multiple therapeutic pathways. Inflammation is also known to be persistent throughout the acne life cycle. “
——Prof. Dr. med. Harald Gollnick & the Global Alliance to Improve Outcomes in Acne
“Inflammation should be addressed via multiple therapeutic pathways. Inflammation is also known to be persistent throughout the acne life cycle.”
——Prof. Dr. med. Harald Gollnick & the Global Alliance to Improve Outcomes in Acne
Struggling with skin redness, itchiness, pain or breakouts? You’re not alone. These common skin woes often stem from one primary culprit: inflammation.
Skin inflammation is the primary cause of acne and aging, it also transform your skin’s appearance and feel, leading to discomfort and self-consciousness.
Research indicates that the plant-derived ingredients CBD, CBG, and Bakuchiol could effectively address all of these skin concerns, thanks to their strong anti-inflammatory properties, making them standout choices in the vast array of skincare products.
Let’s take a look at the many benefits of CBD CBG and Bakuchiol and how these ingredients could help to tackle your skincare concerns.
Exploring the Anti-Inflammatory Potential of CBD with Leading Academics
CBD, or cannabidiol, is a non-psychoactive component of the Cannabis plant known for its potential medicinal benefits without the hallucinogenic effects of its recreational counterparts.
Cannabis has a long history of medicinal use, especially for its anti-inflammatory properties, dating back to 1500 BC in Egypt. Modern studies reveal how CBD, a cannabis derivative, effectively reduces inflammation in skin and various disorders. Research on CBD’s role in skin care, particularly for inflammatory conditions like acne, has advanced significantly in the last four years
Why Does CBD Have Anti-Inflammatory Properties?
CBD has anti-inflammatory properties because it interacts with the body’s endocannabinoid system, affecting various cellular processes and reducing the production of pro-inflammatory cytokines. It modulates immune responses and signaling pathways, such as TRPV1, JAK/STAT, and Adenosine receptors, which are involved in inflammation.
Anti-Inflammatory Mechanisms of CBD
Evaluation of CBD in acne-like conditions revealed suppressed expression of pro-inflammatory cytokines, TNF-α, IL-1β, and IL- 6. Treatment with these cannabis extracts was also found to be safe and well tolerated, further strengthening the prospect of CBD as an anti-inflammatory therapeutic for acne. [1]
Mechanistically, CBD decreases inflammation and subsequent cytokine production through modulation of the immune system and suppression of immune responses.[2]
CBD’s Interaction with Signaling Pathways
CBD’s anti-inflammatory and immunosuppressive properties result from its interaction with key signaling pathways and receptors, not involving CB1 and CB2 receptors directly.[3]
TRPV1 Pathway:
CBD influences the TRPV1 channel, activation of the TRPV1 channel induces pro-inflammatory and immune-mediated responses. CBD mitigates these effects by inhibiting the neural sensitization of TRPV1 or desensitizing its signaling, thereby exerting anti-inflammatory actions. [3,4,5]
Adenosine Receptors:
Additionally, it enhances adenosine signaling, which has anti-inflammatory effects, by blocking adenosine’s cellular uptake. [11,12,13]
JAK/STAT Pathway:
CBD also affects the JAK/STAT pathway by inhibiting specific cytokines, thus regulating immune functions. [3,7,8] CBD also suppresses cytokines initiating the JAK/STAT pathway and prevents the activation of the NLR inflammasome complex. [3,9,10]
Check article The Anti-Inflammatory Effects of Cannabidiol (CBD) on Acne for more detailed information.
Exploring the Anti-Inflammatory Potential of CBG with Leading Academics
Cannabigerol (CBG) is a minor non-psychoactive cannabinoid present in Cannabis sativa L. at low levels (<1% per dry weight) that serves as the direct precursor to both cannabidiol (CBD) and tetrahydrocannabinol (THC). Consequently, the extraction and purification process for CBG from the plant are notably difficult and makes CBG more scarce and valuable.
Evidence Shows That CBG Is More Effective Than CBD in Anti-Inflammation
Perez and colleagues investigated CBG, becoming the first to conduct clinical trials of CBG on human skin. They discovered that CBG can reduce the release of inflammatory cytokines, such as interleukin-1β, -6, -8, and tumor necrosis factor α, which are triggered by various inflammatory sources including UVA and UVB radiation, chemicals, and Propionibacterium acnes, often outperforming CBD in effectiveness. [14]
Significantly, CBG was more effective than CBD in three out of four in vitro inflammation tests. Its anti-inflammatory capabilities in vitro, combined with its clinical effectiveness in reducing skin redness caused by SLS, and its significant improvement in reducing transepidermal water loss and redness, suggest that CBG could be a valuable component in treating various inflammatory skin conditions, including inflammatory acne. [14]
Altogether, CBG’s broad range of in vitro and clinical skin health-promoting activities demonstrates its strong potential as a safe, effective ingredient for topical use and suggests there are areas where it is more effective than CBD.
Check article In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties for more detailed information.
Exploring the Anti-Inflammatory Potential of Bakuchiol with Leading Academics
Bakuchiol is a plant-derived compound often touted as a natural alternative to Retinol. Found in the seeds and leaves of the Psoralea corylifolia plant, bakuchiol has been shown to have antioxidant, anti-inflammatory, and anti-bacterial properties. It is used in skincare for its ability to help reduce signs of aging and combat acne without the irritation commonly associated with Retinol.
Bakuchiol’s impact on photoaging, improves skin texture and elasticity, reduces the appearance of aging, acne, and post-inflammatory hyperpigmentation (PIH), where it has shown benefits similar to those of topical retinoids. While having no structural resemblance to retinoids, Bakuchiol can function as a Retinol analog, through Retinol-like regulation of gene expression. [15]
However, research shows that bakuchiol is better than Retinol in some aspects.
Bakuchiol Has a Stronger Anti-Inflammation Capability
- The Beiersdorf team studied how Bakuchiol and Retinol affect inflammation by looking at two inflammatory markers, PGE2 and MIF. They found both compounds can lower PGE2 levels in skin cells, with Bakuchiol being more effective than Retinol. [16]
- MIF is another proinflammatory cytokine that is ubiquitously expressed in various organs including the skin. [17] Studies show that both Bakuchiol and Retinol similarly lower MIF levels in skin cells, demonstrating their anti-inflammatory effects. [16]
- Bakuchiol inhibits pro-inflammatory enzymes. Bakuchiol has inhibitory activity against pro-inflammatory enzymes, such as phospholipase A2 (PLA2) and dose dependently reduce formation of LTB4 and TXB2. [18] Literature also shows that Bakuchiol has lipooxygenase (LOX) inhibitory activity. [18]
Bakuchiol Is Milder Than Retinol
Bakuchiol is milder than Retinol, with fewer side effects such as dryness and redness. Research by Sytheon shows Bakuchiol effectively reduces two types of inflammation markers, COX-1 and COX-2. Unlike Retinol, which can increase COX-2 at higher doses, Bakuchiol decreases it, possibly explaining why it’s less irritating to the skin. [19]
Bakuchiol Demonstrated High Anti-Oxidative Efficacy in Contrast to Retinol [16]
These results are also in line with previous studies illustrating that bakuchiol decreases oxidative stress, prevents mitochondrial lipid peroxidation and protects mitochondrial function. [21,22] Retinol, however, has not been reported to exert anti-oxidative actions.
All these evidence makes bakuchiol a better option for those with sensitive skin or individuals who find Retinol too harsh but still want comparable anti-acne and anti-aging benefits.
Besides comparing with Retinol, there is study focus on testing the anti-inflammatory effect of Bakuchiol. Brownell and team conducted a single center, open-label pilot study where they observed that bakuchiol reduced acne inflammatory lesion counts by 26.9% at week 8 and 28.4% at week 12. The study aims to evaluate the effectiveness of a topical product containing 0.5% bakuchiol, on facial acne and acne-related post-inflammatory hyperpigmentation (PIH). And 13 participants with mild to moderate acne and Fitzpatrick skin types III to VI underwent bakuchiol treatment twice daily for 12 weeks. [20]
Last but Not Least
Inflammation is a key factor in acne development, and CBD, CBG, and Bakuchiol have proven strong in managing it. These plant-based ingredients not only reduce inflammation but also soothe skin, exhibiting benefits like anti-aging and less irritation compared to traditional treatments. In summary, as natural compounds, CBD, CBG, and Bakuchiol offer effective and gentle solutions for acne-related issues, making them excellent choices in skincare regimens focused on treating and soothing inflamed skin conditions.
Collaborative Research and Discoveries with Leading Universities
Recognizing the potent anti-inflammatory effects of CBD, CBG, and Bakuchiol, VOIBON, in collaboration with the University of Rhode Island College of Pharmacy, has conducted rigorous foundational research over a year to discover the optimal blend of these ingredients. This effort was to determine the optimal ratio of these components, achieving a synergistic effect that enhanced their anti-inflammatory and antioxidant capabilities, demonstrating a “1+1+1>3” effect. A patent has been applied for this innovative discovery.
Besides their potent anti-inflammatory effects, CBD, CBG, and Bakuchiol also show promising anti-aging benefits. These compounds not only soothe inflamed skin but may also reduce signs of aging. We plan to delve into these anti-aging effects in future articles, offering a comprehensive analysis of their skincare potential.
Our carefully researched and developed products embody this innovative blend, offering every user the perfect synergy of science and nature. Visit the VOIBON official website to find the right product for you.
If you wanna dive deeper into how inflammation ties with skincare, hit us up on WhatsApp.
Reference
2. Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry, 1(7), 1333–1349. https://doi.org/10.4155/fmc.09.93
3. Peyravian, N., Deo, S., Daunert, S., & Jimenez, J. J. (2020). Cannabidiol as a Novel Therapeutic for Immune Modulation. ImmunoTargets and therapy, 9, 131–140. https://doi.org/10.2147/ITT.S263690
4. Lowin, T., & Straub, R. H. (2015). Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis research & therapy, 17(1), 226. https://doi.org/10.1186/s13075-015-0743-x
5. Fonseca, B. M., Correia-da-Silva, G., & Teixeira, N. A. (2018). Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. Journal of physiology and biochemistry, 74(2), 261–272. https://doi.org/10.1007/s13105-018-0611-7
6. Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9561–9566. https://doi.org/10.1073/pnas.160105897
7. Kozela, E., Pietr, M., Juknat, A., Rimmerman, N., Levy, R., & Vogel, Z. (2010). Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells. The Journal of biological chemistry, 285(3), 1616–1626. https://doi.org/10.1074/jbc.M109.069294
8. Weiss, L., Zeira, M., Reich, S., Har-Noy, M., Mechoulam, R., Slavin, S., & Gallily, R. (2006). Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity, 39(2), 143–151. https://doi.org/10.1080/08916930500356674
9. Liu, C., Ma, H., Slitt, A. L., & Seeram, N. P. (2020). Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes. Journal of natural products, 83(6), 2025–2029. https://doi.org/10.1021/acs.jnatprod.0c00138
10. Libro, R., Scionti, D., Diomede, F., Marchisio, M., Grassi, G., Pollastro, F., Piattelli, A., Bramanti, P., Mazzon, E., & Trubiani, O. (2016). Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Frontiers in physiology, 7, 559. https://doi.org/10.3389/fphys.2016.00559
11. de Almeida, D. L., & Devi, L. A. (2020). Diversity of molecular targets and signaling pathways for CBD. Pharmacology research & perspectives, 8(6), e00682. https://doi.org/10.1002/prp2.682
12. Carrier, E. J., Auchampach, J. A., & Hillard, C. J. (2006). Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proceedings of the National Academy of Sciences of the United States of America, 103(20), 7895–7900. https://doi.org/10.1073/pnas.0511232103
13. Liou, G. I., Auchampach, J. A., Hillard, C. J., Zhu, G., Yousufzai, B., Mian, S., Khan, S., & Khalifa, Y. (2008). Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. Investigative ophthalmology & visual science, 49(12), 5526–5531. https://doi.org/10.1167/iovs.08-2196
14. Perez, E., Fernandez, J. R., Fitzgerald, C., Rouzard, K., Tamura, M., & Savile, C. (2022). In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties. Molecules (Basel, Switzerland), 27(2), 491. https://doi.org/10.3390/molecules27020491
15. Puyana, C., Chandan, N., & Tsoukas, M. (2022). Applications of bakuchiol in dermatology: Systematic review of the literature. Journal of cosmetic dermatology, 21(12), 6636–6643. https://doi.org/10.1111/jocd.15420
16. Bluemke, A., Ring, A. P., Immeyer, J., Hoff, A., Eisenberg, T., Gerwat, W., Meyer, F., Breitkreutz, S., Klinger, L. M., Brandner, J. M., Sandig, G., Seifert, M., Segger, D., Rippke, F., & Schweiger, D. (2022). Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing – Experimental evidence for a holistic treatment approach. International journal of cosmetic science, 44(3), 377–393. https://doi.org/10.1111/ics.12784
17. Calandra, T., & Roger, T. (2003). Macrophage migration inhibitory factor: a regulator of innate immunity. Nature reviews. Immunology, 3(10), 791–800. https://doi.org/10.1038/nri1200
18. Ferrándiz, M. L., Gil, B., Sanz, M. J., Ubeda, A., Erazo, S., González, E., Negrete, R., Pacheco, S., Payá, M., & Alcaraz, M. J. (1996). Effect of bakuchiol on leukocyte functions and some inflammatory responses in mice. The Journal of pharmacy and pharmacology, 48(9), 975–980. https://doi.org/10.1111/j.2042-7158.1996.tb06016.x
19. Chaudhuri, R. K., & Marchio, F. (2011). Bakuchiol in the management of acne-affected skin. Cosmetics & Toiletries, 126(7), 502-510.
20. Brownell, L., Geen, S., E, Y., & Lee, W.-L. (2021). A Clinical Study Evaluating the Efficacy of Topical Bakuchiol (UP256) Cream on Facial Acne. Journal of Drugs in Dermatology, 20(3), 307–310. https://doi.org/10.36849/jdd.2021.5655
21. Haraguchi, H., Inoue, J., Tamura, Y., & Mizutani, K. (2000). Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia. Planta medica, 66(6), 569–571. https://doi.org/10.1055/s-2000-8605
22. Adhikari, S., Joshi, R., Patro, B. S., Ghanty, T. K., Chintalwar, G. J., Sharma, A., Chattopadhyay, S., & Mukherjee, T. (2003). Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain. Chemical research in toxicology, 16(9), 1062–1069. https://doi.org/10.1021/tx034082r
